Disopyramide: Although potentially life-threatening in the setting of long QT, could it be life-saving in short QT syndrome?
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چکیده
منابع مشابه
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متن کاملGenotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias.
BACKGROUND The congenital long-QT syndrome (LQTS) is caused by mutations on several genes, all of which encode cardiac ion channels. The progressive understanding of the electrophysiological consequences of these mutations opens unforeseen possibilities for genotype-phenotype correlation studies. Preliminary observations suggested that the conditions ("triggers") associated with cardiac events ...
متن کاملRisk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals.
OBJECTIVES This study was designed to assess the clinical course and to identify risk factors for life-threatening events in patients with long-QT syndrome (LQTS) with normal corrected QT (QTc) intervals. BACKGROUND Current data regarding the outcome of patients with concealed LQTS are limited. METHODS Clinical and genetic risk factors for aborted cardiac arrest (ACA) or sudden cardiac deat...
متن کاملLong QT syndrome and life threatening arrhythmia in a newborn: molecular diagnosis and treatment response.
Intrauterine and neonatal manifestations of congenital long QT syndrome are associated with a high cardiac risk, particularly when atrioventricular block and excessive QT prolongation (> 600 ms(1/2)) are present. In a female newborn with these features, treatment with propranolol and mexiletine led to complete reduction of arrhythmia that was maintained 1.5 years later. High throughput genetic ...
متن کاملRelation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans.
BACKGROUND Recent molecular biological investigations have identified abnormal genes in familial forms of long QT syndrome, but in bradycardia dependent acquired long QT syndrome, no such genetic abnormality has yet been identified. OBJECTIVE To investigate the relation between the responses of QT interval to pacing change and to disopyramide. METHODS This study included 13 patients with br...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2006
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2006.06.070